This region forms not only the main north-south corridor to the Mediterranean, but in medieval times was also the boundary between France and Germany. It includes two major shrines: La Motte, now known as St Antoine l'Abbaye, and St Maximin, which together with the Ste Baume replaced Vézelay as the centre of the cult of Mary Magdalene after the 13th century.
The two main routes into this from the north are from the Seine valley, crossing the watershed at St Seine l'Abbaye, and from the Rhine valley at Basel/Mulhouse via the Doubs valley. From the east, routes from Lake Geneva run to either Lyon or Chambéry and Valence. The only Jura crossing in the itineraries runs between Pontarlier and Lausanne.
In the valley itself, the main node is Lyon, the regional capital, from where an important road runs east over the Mont du Chat to Chambéry (and on to Mt Cenis via the Maurienne). North of Lyon, a variation on the main road is to the west via Cluny. In the south, in the delta, I use Avignon as the node. This is a simplification, as several itineraries bypass Avignon to the west.
W of the delta, the route is the Via Domitia via Montpellier, the main road from Roman times to today. Similarly, to the east, the route is via Aix to St Maximin (and on to Nice and Italy), also largely based on the Roman road.
The Codex Calixtinus claims that travellers from the east to the W Pyrenees crossed the Massif Central via Le Puy. This is an unlikely route, but Estienne does include a road from Montauban via Rodez to Le Puy, a route also followed by Bartolomeo Fontana.